Cells from advanced malignant tumors often have very abnormal chromosomes as wel

Question

Cells from advanced malignant tumors often have very abnormal chromosomes as well as an abnormal number of chromosomes. What might explain the association between malignant tumors and chromosomal abnormalities?

A) Chromosomally abnormal cells still have normal metabolism.
B) Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities.
C) Cancer cells are no longer anchorage dependent.
D) Cancer cells are no longer density dependent.
E) Transformation introduces new chromosomes into cells.

Explanation / Answer

B) Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities. E) Transformation introduces new chromosomes into cells. Anchorage dependence/Metastasis do not have any relation to the association between malignant tumors and chromosomal abnormalities, although very true.

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