Question 17 52 1 pts 2 Que Time Elapsed Attempt due: Ap 22 Hours, 1h Describe tw

Question

Question 17 52 1 pts 2 Que Time Elapsed Attempt due: Ap 22 Hours, 1h Describe two pieces of evidence supporting the idea that cancer cells secrete molecules that stimulate angiogenesis. In a normal tissue cancer cells grow to reach enormous size. As the size increases the amount of blood vessels in the surrounding host tissues increases significantly. When cancer cells are removed after surgical intervention, some blood vessel cells die to reject the total amount of vessels. The only conclusion is that cancer cells produce molecules that activate angiogenesis is Cancer cells when injected into mice with mutated blood vessels secrete proteins that profiltrate through blood vessel tissue and link up to the mutated blood vessels. Then these proteins produce endothelial cells that replace mutated cells, and so repair blood vessels. After all vessels are repaired new blood vessels start to grow. When cancer cells are placed in a chamber surrounded by a filter possessing tiny pores that cells cannot pass through, and the chamber is then implanted into animals, new capillaries proliferate in the surrounding host tissue. Since the cancer cells cannot pass through the filter, the most straightforward interpretation is that the cells produce molecules that diffuse through the tiny pores in the filter and activate angi surrounding normal tissue. ] ogenesis in the Cancer cells produce and secrete angiogenesis-activating proteins called vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), which bind to receptor proteins on the surface of endothelial cells. The activated endothelial cells then organize into hollow tubes that develop into new blood vessels. Next

Explanation / Answer

Cancer cells produce and secrete angiogenesis-activating proteins called vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), which binds to receptor protein on the surface of endothelial cells. The activated endothelial cells then organize into hollow tubes that develop into new blood vessels.

When cancer cells are placed in a chamber surrounded by a filter possessing tiny pores that cells cannot pass through, and the chamber is then implanted into animals, new capillaries proliferate in the surrounding host tissue. Since the cancer cells cannot pass through the filter, the most straightforward interpretation is that the cells produce molecules that diffuse through the tiny pores in the filter and activate angiogenesis in the surrounding normal tissue.

The other two option doesn’t support the idea of cancer cells secreting molecule that stimulate angiogenesis.

The idea of angiogenesis can be supported only when there is secretion of angiogenesis-activating factor by the cancer cells which promotes the formation of new blood vessels.

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