Which of the following is/are TRUE concerning the cell cycle? (Select ALL that a

Question

Which of the following is/are TRUE concerning the cell cycle? (Select ALL that are TRUE.)

Question 1 options:

a)

The cell cycle stage called “M phase” is part of interphase.

b)

Replication of DNA in preparation for division occurs during interphase of the cell cycle.

c)

The mitotic spindle is assembled during M phase of the cell cycle.

d)

Signals to proliferate, such as growth factors, are important at the G2 to Mcheckpoint.

e)

As long as there are sufficient nutrients, all animal cells will continue proliferating.

Which of the following is/are TRUE statements regarding the cell cycle? (Select ALL that are TRUE.)

Question 2 options:

a)

The amount of cyclin protein present in a cell changes, being high at only particular stages of the cell cycle.

b)

Sharp declines in the level of a cyclin in the cytosol occur due to ubiquitylation and subsequent degradation in a lysosome.

c)

To be active, cyclin-dependent kinases must be phosphorylated on the activation loop (also called the T loop) present in the kinase catalytic domain.

d)

To be active, cyclin-dependent kinases must bind to a cyclin.

e)

In normal cells, the activated forms of tumor suppressor proteins Rb and p53 both work to inhibit progression through the cell cycle.

Which of the following is/are TRUE statements? (Select ALL that are TRUE.)

Question 3 options:

a)

Both myosin and kinesin are motor proteins that form dimers in which alpha helices associate in a coiled coil.

b)

A myosin motor “walks” along microtubules by binding to the microtubule through its motor domain.

c)

An action potential fired in the plasma membrane of a muscle cell will propagate into the cell interior through the T-tubules, which are invaginations of the plasma membrane.

d)

Sarcomeres shorten during muscle contraction.

e)

The release of Ca++ from the sarcoplasmic reticulum into the cytosol of the muscle cell causes muscle contraction by changing the position of tropomyosin on the actin filament.

a)

The cell cycle stage called “M phase” is part of interphase.

b)

Replication of DNA in preparation for division occurs during interphase of the cell cycle.

c)

The mitotic spindle is assembled during M phase of the cell cycle.

d)

Signals to proliferate, such as growth factors, are important at the G2 to Mcheckpoint.

e)

As long as there are sufficient nutrients, all animal cells will continue proliferating.

Explanation / Answer

1. Replication of DNA in preparation for divisions occurs during interphase of cell cycle.

The mitotic spindle is assembled during M phase of the cell cycle.

2. To be active , cyclin dependent kinases must be phosphorylated on the activation loop present in the kinase catalytic domain.

To be active , cyclin dependent kinase must bind to cyclins.

In normal cell, the activated forms of tumor suppressor proteins Rb and p53 both work to inhibit progression through cell cycle.

3. A myosin motor walks along microtubules by binding to the microtubule through its motor domain.

Sarcomere shorten during muscle contraction.

The release of Ca++ from the sarcoplasmic reticulum into the cytosol of the muscle cell causes muscle contraction by changing the position of tropomyosin on the actin filament.

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