Some cancer cells are able to proliferate when they \"don\'t have permission\" f
ID: 260082 • Letter: S
Question
Some cancer cells are able to proliferate when they "don't have permission" from the body. Which of the following might account for this?
A cell makes its own mitogens and secretes them in an autocrine fashion.
A cell acquires a mutation in a G1 Cdk that prevents it from binding its respective cyclin.
A cell acquires a mutation in Rb that prevents it from being phosphorylated by Cdk/cyclin complexes.
A cell acquires an inactivating mutation in a mitogen receptor.
?AA cell makes its own mitogens and secretes them in an autocrine fashion.
?BA cell acquires a mutation in a G1 Cdk that prevents it from binding its respective cyclin.
?CA cell acquires a mutation in Rb that prevents it from being phosphorylated by Cdk/cyclin complexes.
?DA cell acquires an inactivating mutation in a mitogen receptor.
Explanation / Answer
Answer is C.
Rb - Retinoblastoma is a tumour suppresor protein which is in unphosphrylated form bond to E2F and inhibits the progression of cell cycle. So mutation in Rb does not allow it to phosphorylate and cell do not proliferate.
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