Which strand of the double-stranded siRNA is cut in two and then dissociates fro
ID: 260088 • Letter: W
Question
Which strand of the double-stranded siRNA is cut in two and then dissociates from the pre-RISC?
the active strand
the passenger strand
the siRNA strand
the pedestrian strand
the silencer strand
2) A pri-mRNA is cleaved within the nucleus by an enzyme called _______ into a shorter, double-stranded, hairpin-shaped precursor called a ________.
Drosha,
pre-miRNA Drosha,
pri-miRNA Dicer,
pre-miRNA Dicer,
pri-miRNA Slicer,
pre-miRNA
3) With what protein does the double-stranded miRNA become associated?
The RNA duplex then is disassembled and one of the single strands is incorporated into a RISC complex.
slicer
Mincer
an Argonaute protein
riscin
ribonuclease
4) Peptide bond formation is accomplished as the amine nitrogen of the aa-tRNA in the ______ carries out a _________ of the amino acid bound to the _______.
A site, nucleophilic attack on the carbonyl carbon, tRNA of the P site
P site, nucleophilic attack on the carbonyl carbon, tRNA of the A site
A site, acidophilic attack on the carbonyl carbon, tRNA of the P site
A site, electrophilic attack on the carbonyl carbon, tRNA of the P site
5) Which of the following mutations is likely to be the least harmful?
A +1 frameshift
A +3 frameshift
A -1 frameshift
None of these
6) If there were one tRNA for every codon that codes for an amino acid, how many different tRNAs should there be?
20
3
64
61
21
7) Which codon below usually serves as the initiation codon?
5'-AUG-3'
5'-GUG-3'
3'-AUG-5'
3'-GUG-3'
3'-UAC-5'
Explanation / Answer
1. the passenger strand
The passenger strand is cleaved and is dissociated from the pre-RISC.
2. Drosha, pre-miRNA
In miRNA processing drosha cleaves pri-mRNA to form pre- miRNA
3. an Argonaute protein
The double-stranded miRNA become associated with Argonaute protein which then retains only the guide strand.
The RNA duplex then is disassembled and one of the single strands is incorporated into a RISC complex.
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