2. You are studying a recently discovered kinase PK10047 and trying to determine

Question

2. You are studying a recently discovered kinase PK10047 and trying to determine what its target protein(s) are. You have found that PK10047 is activated through GPCR signaling. When PK10000047 is active, you see a rapid reduction in the level of the protein Gammatap A) What are two ways PK10047 could cause the levels of Gammatap to rapidly decline? B) For one of your answers in part A, describe in a stepwise fashion, the molecular steps that would occur that result in Gammatap's degradation. (Hint: think of a pathway) C) Explain one hypothesis for why it could be an advantage to the cell to degrade Gammatap instead of inactivating it.

Explanation / Answer

(A) PK10047 can cause the levels of Gammatap to rapidly decline in two ways -

(B) For case 1: PK10047 can degrade Gammatap by catalyzing the reaction of its degradation using GPCR signaling.

Since PK10047 is activated by G-protein coupled receptor signaling, it results in Gammatap's degradation by the following steps -

(C) It can be advantageous fo the cell to degrade Gammatap instead of inactivating it because -

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