QUESTION 8 Place the following aspects of the miRNA pathway in the correct order

Question

QUESTION 8 Place the following aspects of the miRNA pathway in the correct order from first to last. Translation of targeted mRNAs is blocked A gene with an inverted repeat is transcribed Dicer generates 25 bp long pieces of double-stranded RNA The RISC complex incorporates a double stranded RNA fragment QUESTION 9 CRCs, DNA methylation, and histone modification are all examples of Postranslational modification Autoregulation Cis regulatory elements Epigenetic modification QUESTION 10 Which of the following is generally associated with transcriptional activation (select all that apply)? CRC activity J Cytosine methylation Histone methylation Histone acetylation

Explanation / Answer

8. Steps in miRNA pathway:

I. A gene with an inverted repeat is transcribed

II. Dicer generates 25 bp long pieces of dsRNA

III. The RISC complex incorporates a double-stranded RNA fragment

IV. Inhibition of translation

9. Option D is correct.

CRCs, DNA methylation, and histone modifications are all examples of epigenetic modifications.

10. Option D is correct.

Histone acetylation is associated with transcriptional activation.

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