Which statement regarding ketone bodies is FALSE? A. The production of ketone bo
ID: 261612 • Letter: W
Question
Which statement regarding ketone bodies is FALSE?
A. The production of ketone bodies increases when blood glucagon levels are elevated
B. Ketone bodies are produced under metabolic conditions that are also associated with loss of muscle mass and enhanced gluconeogenesis
C. In hepatocytes, the production of ketone bodies is an anaplerotic process because the products of Beta-hydroxybutyrate oxidation can enter the citric acid cycle
D. Ketone bodies are produced by the liver during starvation or in cases when insulin production is insufficient
E. The production of excess ketone bodies can cause a conditition known as ketosis, which is associated with acidosis
Explanation / Answer
Answer: Choice C
Reason: Ketogenesis is a process of generation of ketone bodies which starts from acetyl-coenzyme A as a substrate and is converted into three types of ketone bodies by sequential enzymatic activities. Thus, the product of beta hydroxybutyrate oxidation itself does not enter citric acid cycle, but the product of citric acid cycle is utilized in beta hydroxybutyrate oxidation to generate ketone bodies.
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