Discuss why ketone bodies become an important fuel for extrahepatic tissues when

Question

Discuss why ketone bodies become an important fuel for extrahepatic tissues when the individual moves from a post-absorptive state to a fasting/starvation state. Where are ketone bodies formed? What is their purpose? If acetyl-coA was used to manufacture 25 molecules of acetoacetic acid and 30 molecules of ?-hydroxy-butyric acid, what would be the final ATP generation if each of these molecules was broken down in the TCA cycle in the muscle. Be specific and draw out the reactions that would happen to help justify your answer.

Explanation / Answer

1.During starvation carbohydrate are not present ,then stored fat has to be metabolized for energy. 2.Ketone bodies are produced from acetyl-CoA mainly in the mitochondrial matrix of hepatocytes when carbohydrates are scarce and energy is obtained from breaking down fatty acids 3.In the brain, they are a vital source of energy during fasting. 660 ATP formed during each tca cyle 12 ATP are produced from.

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