\"Repair of DNA damage caused by cytosine deamination in mitochondrialDNA of for

Question

"Repair of DNA damage caused by cytosine deamination in mitochondrialDNA of forensic case samples" by Erin M. Gordena, Kimberly Sturk-Andreaggia, and Charla Marshall. It was published in Forensic Science International: Genetics, Volume 34, May 2018, Pages 257-264 (open access).

- What do you thing about the number of examined samples ? Are 21 degraded forensic skeletal samples enough to conclude on the effects of DNA repair technique ?

- Why cytosine deamination was observed in ancient and degraded samples ?

- Which is the limitation of Sanger-type sequencing (STS) method ?

- Which enrichment methods were used to target a portion of mtDNA CR and the mitogenome ?

- How was assessed the level of DNA damage present in the untreated and repaired amplicon NGS data ?

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