Mohammad C Secure https://learn.kent.edu/bbcswebdav/pid-8152838-dt-content-rid-9

Question

Mohammad C Secure https://learn.kent.edu/bbcswebdav/pid-8152838-dt-content-rid-94838813_1/courses/11331-11342-22012-22032.201810/Problem%20set%20%20ch%20.-Q ? Problem set Ch. 3,13, 14,16 for 4.13.18(1).pdf 416 12. You are interested in how cyclic-AMP-dependent protein kinase A (PKA) functions to affect learning and memory, and you decide to study its function in the brain. It is known that, in the cells you are studying, PKA works via a signal transduction pathway like the one depicted in the Figure below. Furthermore, it is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activates transcription of the gene Brainy. Which situation described below will lead to an increase in Brainy activated adenylyl rcce ecbuated nuclear pore UCLEUS tranecriptien TRANSCRIPTION OF (a) (b) (c) amutation of the transcriptional regulator Nerd that produces a protein that cannot be phosphorylated by PKA a mutation in the nuclcar import sequence of PKA so that PKA can't be imported in to the nuclcus. an inhibitor of cAMP phosphodiesterase that makes the enzyme inactive a mutation in the gene that encodes adenylyl cyclase that renders the enzyme unable to interact with the a subunit of the G protein (d)

Explanation / Answer

The mutation in the gene that code for cAMP phosphodiesterase that in turn make the enzyme inactive is responsible for increasing the transcription.

Hence, option c is correct.

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