Mohammad C secure https: learn.kent.edu/bbcswebdav/pid-8152838-dt-content-rid-94

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Mohammad C secure https: learn.kent.edu/bbcswebdav/pid-8152838-dt-content-rid-94838813_1/courses/11331-11342 22012-22032.201810/Problem%20set%20%20ch%20… Q ? Problem set Ch. 3,13, 14,16 for 4.13.18(1).pdf 616 14. The Figure below shows how normal signaling works with a Ras protein acting downstream of an RTK. You examin?a cell line with a constitutively active Ras protein that is always signaling. Which of the following conditions will turn off signaling in this cell line? HORMAL SIGNAUING REQUIRES R AND TWO PROTEINS XAND Y ctive Ras prote n CYTOSOL actoive signaling tyiosine kinase protein X (a) (b) (c) (d) addition of a drug that prevents protein X from activating Ras addition of a drug that increases the affinity of protein Y and Ras addition of a drug that blocks protein Y from interacting with its target addition of a drug that increases the activity of protein Y 15. In the Figure above, protein X activates ras. Wbat type of protein could protein X be? (a) a GTPase activating protein (GAP) (b) a MAP kinase (c) an adaptor protein (d) a guanine exchange factor (GEF) 16 You are interested in cell-size regulation and discover that signaling through a GPCR called ERC1 is important in controlling cell size in embryonic rat cells. The G protein downstream of ERC1 activates adenylyl cyclase, which ultimately leads to the activation of PKA. You discover that cells that lack ERC are 15% smaller than normal cells, while cells that express a mutant, constitutively activated version of PKA are 15% larger than normal cells. Given these results, which of the following treatments to embryonic rat cells should lead to smaller cells? (a) (b) (c) (d) addition of a drug that causes cyclic AMP phosphodiesterasc to be hypcractive addition of a drug that prevents GTP hydrolysis by Ga addition of a drug that activates adenylyl cyclase addition of a drug that mimics the ligand of ERCI

Explanation / Answer

14. a) Addition of drug that prevents protien X from activating Ras

15. d) A guanine exchange factor (GEF)

16. a) addition of a drug that causes cyclic AMP phosphodiesterase tobe hyperactive

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