2a. There are four forms of the enzyme hexokinase that normally exist in humans.

Question

2a. There are four forms of the enzyme hexokinase that normally exist in humans. These different forms are called isozymes or isoforms. All forms will have the ability to catalyze step one of glycolysis but are not regulated in the exact same manner. (2 points) 2ai. Why do you think having isozymes of some enzymes present is advantageous in an organism with different cell types? 2aii. How do you suspect these enzymes are related to but distinct from one another? 2b. Liver cells and muscles cells utilize two different forms of hexokinase. The liver hexokinase differs from the muscle hexokinase in at least 2 ways as outlined in the table below: Hexokinase enzyme KM for glucose in source Liver cells Muscle cells The enzyme is inhibited by Glucose- 6-phosphate? mM Yes 2bi. If both enzymes are present at the same concentration what would you expect to be true for these two enzymes with respect to their enzymatic activity in the presence of 5mM glucose? Which enzyme, if either, would be operating at Vmax? (1 point) 2bii. What type of inhibitor would you suspect glucose-6-phosphate is and briefly explain your answer? (1 points)

Explanation / Answer

2a. There are four forms of the enzyme hexokinase that normally exist in humans.

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