4A. (3pts) One Please put an an \"I next of the following statements is generall

Question

4A. (3pts) One Please put an an "I next of the following statements is generally accurate, and the other one is not. next to the accurate statement and provide a supporting example. Please put o the inaccurate statement and provide a counter-examplo. GEF's activate signaling proteins, while GAP's inactivate them Supporting or counter-example: Kinases activate signaling proteins, while phosphatases inactivate them. B. (apts) Do you AGREE or DISAGREE with the following? Please provide your reasoning. The changes that kinases and Circle: phosphatases make to proteins are both energetically favorable. AGREE DISAGREE 5. In a biotech start-up, your goal is to develop & study drugs that can target RTK pathways that can lead to cancer. You decide to focus on the following pathway EGFR Grb2Sos RasRMek Erk Downstream response (cell proliferation) A. (2pts) Select one protein in this pathway. What molecular effect could your drug have on this protein to lead to increased cell division?

Explanation / Answer

4A. (1) GEF... A ( accurate )

Reason = GEF is exchange factor that activate GPCR and GAP hydrolyse GTP to inactive corresponding protein.

(2) kinase activate. ... I (inaccurate)

Reason = like kinase inactivated MLCP by phosphorylation and phosphatase active MLCP by dephosphorylation .

B. Agree because phosphorylation and dephosphorylation are simultaneously occur to stimulate or inhibit a protein function.

5.(A) If a drug make Ras mutant as it always bind with GTP then cell will divide continuously .

(B) If Ras again repair and increase its GTPase activity then it will become resistant to that particular drug.

(C) GEF factor should always active so that drug can not inhibit its activity and Ras can do its normal function.

6. A= decreased

B = decreased

C = increased

D = decreased

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