6. What is meant by \"paired-end reads\" in next generation whole genome sequenc
ID: 266785 • Letter: 6
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6. What is meant by "paired-end reads" in next generation whole genome sequencing? All reads have a 3' to 5' and 5' to 3' pair. Sequencing is performed on pairs of related samples to generate comparable reads. All reads fit end-to-end when aligned to a reference genome. pairs of reads are used to obtain the sequences for the ends of each chromosome. All reads have a "mate" with a known distance between the read and its mate. 10. You are conducting a study to quantify copy number variations (CNVs) in the genomes of cancer patients. You use CGH to obtain hybridization signals for each sample. In one sample you see an increase in signal at one location that is 24x higher than the majority of the signal that you see in the rest of the genome. What does this imply about the copy number of the sequence at that location and the variation that occured? There was a 48x increase in copy number with new copies at that location in the genome. There was a 24x increase in copy number, but the location of the extra copies in the genome is unknown. The CGH results are erroneous. There was a 24x increase in copy number with new copies at that location in the genome. There was a 12x increase in copy number with new copies at that location in the genome. 11. Which of the following is addressed by performing chromatin immunoprecipitation (ChIP) technique? The identity of active promoters on genome-wide level The location of modified histones that activate or repress transcription The identity of the DNA sequence where a particular protein binds The types of modification done on the DNA-binding proteins The position of transcription factors and associated regulators on the chromosome 6. What is meant by "paired-end reads" in next generation whole genome sequencing? All reads have a 3' to 5' and 5' to 3' pair. Sequencing is performed on pairs of related samples to generate comparable reads. All reads fit end-to-end when aligned to a reference genome. pairs of reads are used to obtain the sequences for the ends of each chromosome. All reads have a "mate" with a known distance between the read and its mate.Explanation / Answer
6 Answer:-All readhave 3-5 and 5-3pair.
1 1Answer:-the identity of the DNA sequence where a plarticular protein binds.
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