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If I’m taking a drug like an SSRI to treat depression, and notice that after the

ID: 266843 • Letter: I

Question

If I’m taking a drug like an SSRI to treat depression, and notice that after the first week the drug is not working to improve mood, we might hypothesize that:

a. Heteroreceptors located on the presynaptic cell that monitor and regulate the release of serotonin have not habituated to the increased synaptic concentration of the ligand.

b. Autoreceptors located on the presynaptic cell that monitor and regulate the release of serotonin have habituated to the increased synaptic concentration of the ligand.

c. Heteroreceptors located on the postsynaptic cell that monitor and regulate the release of serotonin have not habituated to the increased synaptic concentration of the ligand.

d. Autoreceptors located on the presynaptic cell that monitor and regulate the release of serotonin have not habituated to the increased synaptic concentration of the ligand.

Explanation / Answer

d. Autoreceptors located on the presynaptic cell that monitor and regulate the release of serotonin have not habituated to the increased synaptic concentration of the ligand.

Basically, it takes time for the neurons producing serotonin receptors to understand that the concentration of serotonin is regulated high enough at the synapse and there is not much need of the receptors on the presynaptic cell to collect it back.

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