aggregation or clearance of amyloid beta plaques are mechanisms proposed contrib

Question

aggregation or clearance of amyloid beta plaques are mechanisms proposed contribute to the role of the APOE protein in Alzheimer risk. It is important to note that the presence of an APOE E4 allele only changes the risk of developing late-onset Alzheimer's disease. Not all carriers of one or two APOE ?4 alleles will develop Alzheimer's disease, and not having any APOE 84 still confers a general population lifetime risk of developing late-onset Alzheimer's disease. This is due to other, yet unknown risk factors 1. Based on the function of the APOE protein, do you think there any other diseases that may be associated with defects in APOE?

Explanation / Answer

Answer

Apolipoprotein E (ApoE) is a class of proteins important in Alzheimer's disease, cardiovascular disease, age related hearing loss, Atherosclerosis, and malaria. ApoE is primarily produced by the liver and macrophages, and mediates cholesterol metabolismThis protein is not involved in establishment of parkinson.

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