Detoxification enzymes are abundant in the smooth endoplasmic reticulum. These e

Question

Detoxification enzymes are abundant in the smooth endoplasmic reticulum. These enzymes specialize in modifying poisons to make them more soluble. The liver detoxifies alcohol, but only up to a point Which best explains how long-term use of alcohol ultimately overwhelms the liver so it is no longer able to compensate efficiently? O by detoxification through proliferation after cells become tolerant O by killing the enzymes needed to detoxify alcohol by chemically altering the molecular structure of alcohol from a carbohydrate to a protein O by inhibiting transport vesicles within the ER

Explanation / Answer

Answer: B (by killing enzymes needed to detoxify enzymes)

Explanation: In liver, ethanol is usually detoxified by detoxification enzymes, when ethanol is metabolized into acetaldehyde, in addition to latter, it also form free radicals like hydroxyethyl radicals. The latter binds with the hepatocellular proteins causing their conformational changes. The proteins may also involve the detoxifying enzymes needed to detoxify alcohol.

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