6. Cystic fibrosis (CF) is an inherited disorder caused by different types of mu

Question

6. Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which prevent ions from moving across cell membranes. Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct amino acid sequence. However, they fail to do their job. A) Given that the primary structure of the protein is correct, what can you infer about the DNA sequence of this patient, is there a mutation? Explain. B) Why is the primary structure insufficient to guarantee the proper function of the protein? Answer these questions thoroughl and

Explanation / Answer

In the case of cystic fibrosis the gene affected is CFTR. Both the copies of this gene should have mutation for having this defect. In the given case the person has mutation but only in the single gene.

The primary structure is insufficient to guarantee the proper function of the protein because it is tertiary structure that mainly affect the function of the protein. If there will be mutation in both the genes than the tertiary structure will be affected.

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