?me Recitation head 6) (14 pts) MALE SEX DETERMINATION PAX 2 SF1 GATA4/FOG2 IRR,

Question

?me Recitation head 6) (14 pts) MALE SEX DETERMINATION PAX 2 SF1 GATA4/FOG2 IRR, POD LHDR, CBX2 SF1 ATRX, DMRT? DAXI DHH, DAXI Vanin-1, Nexlo-1 RSP01 -Catenin FOXLZ NGF, PDGF Sertoli cell TESTIS Leydig cell Part of the HUMAN sex determination pathway is shown above. For A-D, circle the statements that are true and correet the statements that are false. repression Arrows between genes indicates activation,- indicate A. Men do not have dosage compensation. B. In X0 and XXX women, the X:A ratio are 1:1 and 3:1, respectively. C. XX human males can arise from non-disjunction during meiosis. D. XYY humans show no dosage compensation. E. Four brothers in a family were found to be 46, XX, sry-; there was no trace of the Y chromosome (including sry) anywhere in their genomes. There are also no mutations in the promoter, repressor/enhancer elements, or coding region of the Sox9 gene. In ONE sentence, suggest where a mutation has occurred in the sex determination pathway to give rise to the four 46, XX, sry- brothers. F. Suppose that there is a RARE case of a fertile 46, XX, sry+ male. In ONE sentence, what will be the sex and genotype of the children this male can have?

Explanation / Answer

A. True.

Dosage compensation is a mechanism by which the activity of X-linked genes is made equal in the two sexes of the type XX and XY. This is achieved by the inactivation of one X chromosome in somatic cells of females.

Related Questions

Navigate

• Browse (All)
• Browse #
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.