Cells The normal asparagine concentration in human cells (and cancer cells) is 2

Question

Cells The normal asparagine concentration in human cells (and cancer cells) is 2.0 x 10-3M. Considering the catalytic properties of the enzymes shown below, asparaginase purified from which bacterial strain would be the most effective drug for lowering asparagine concentrations in human tissues? Clearly explain your answer. Vmax Kcat Bacterial Strain Pseudomanas aeruginosa4.6 x 102M 2.6x 103 mmol Asn/min 3000 sec Bacillus subtilis Escherichia coli Km 1.1 x 103M 1.9x 103 mmol Asn/min 2000 sec 2.8 x 102M 2.9 x 103 mmol Asn/min 4000 sec

Explanation / Answer

The normal asparagine concentration in human cells (and cancer cells) = 2.0 * 10-3 M (given)

Thus, any asparaginase having a higher Km than this can't be able to work effectively to reduce the asparagine burden from cell.

Among given three source of enzymes the Km Values are : (1.1*10-3 M < 2.8*10-2 M < 4.6*10-2 M) ... shows, only the asparaginase from Bacillus subtilis (with the Km value of 1.1*10-3 M) have proper criteria for the situation where the normal substrate concentration is 2.0*10-3 M (given).

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