IThe Gene Book 27) You and your mate are both heterozygous for some simple Mende

Question

IThe Gene Book 27) You and your mate are both heterozygous for some simple Mendelian gene alpha (ie, each Of you has genotype Aa, and both of you show the dominant phenotype) on dromosome #1. Over the next decade, you proceed to have four children. What is the probability that 3 of your children will show the dominant phenotype and one will show the recessive phenotype? 28) Jessie and Joe are both carriers of the sickle cell trait which causes sickle cell disease when present in the recessive form. What is the likelihood that they will have 2 children, both of whom have the disorder? count phenotypes of his latest genetic cross. The parents were each dihybrid for purple flowers dominant) and tall plant height [dominant]. He has counted about 35 plants so far. If the Law of Independent Assortment is correct, about how many of these plants should be tall and purple? 10) Millie and James are planning to start a family. They just received the tragic news that DNA tests have shown that James brother Jason has the gene for Huntington's Disease [HDI, an autosomal dominant disorder. Without further information about James's DNA, what is the likelihood that this couple could have a child with HD? Should James be tested to see if he has the defective gene? REFERENCES Quinton, PM. "Physiological basis of cystic fibrosis: a historical perspective." Physiol Rev 79 Suppl) (1999): 3-22

Explanation / Answer

1)

as punnet square showed that 75% will be dominant and 25% will be recessive.

so the probabilities will be 3/4 for dominant and 1/4 for recessive.

2)

as there is 1/4 probability for 1 sickle cell child (aa) so 2 child having sickle cell will be = 1/4*1/4 = 1/16.

A a A AA Aa a Aa aa

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