What would happen to the mitochondrial proton gradient, mitochondrial respiratio

Question

What would happen to the mitochondrial proton gradient, mitochondrial respiration (mitochondrial oxygen consumption), and the NADH oxidation rate in cells treated with carbonyl cyanide-4-trifluoromethoxyphenylhydrazone (FCCP), a molecule that increases the permeability of the inner mitochondrial membrane to protons?
Part 1. The mitochondrial proton gradient would: A. Increase B. Decrease
Part 2. Mitochondrial respiration (mitochondrial oxygen consumption) would: A. Increase B. Decrease
Part 3. The NADH oxidation rate would:
A. Increase B. Decrease
What would happen to the mitochondrial proton gradient, mitochondrial respiration (mitochondrial oxygen consumption), and the NADH oxidation rate in cells treated with carbonyl cyanide-4-trifluoromethoxyphenylhydrazone (FCCP), a molecule that increases the permeability of the inner mitochondrial membrane to protons?
Part 1. The mitochondrial proton gradient would: A. Increase B. Decrease
Part 2. Mitochondrial respiration (mitochondrial oxygen consumption) would: A. Increase B. Decrease
Part 3. The NADH oxidation rate would:
A. Increase B. Decrease
What would happen to the mitochondrial proton gradient, mitochondrial respiration (mitochondrial oxygen consumption), and the NADH oxidation rate in cells treated with carbonyl cyanide-4-trifluoromethoxyphenylhydrazone (FCCP), a molecule that increases the permeability of the inner mitochondrial membrane to protons?
Part 1. The mitochondrial proton gradient would: A. Increase B. Decrease
Part 2. Mitochondrial respiration (mitochondrial oxygen consumption) would: A. Increase B. Decrease
Part 3. The NADH oxidation rate would:
A. Increase B. Decrease
What would happen to the mitochondrial proton gradient, mitochondrial respiration (mitochondrial oxygen consumption), and the NADH oxidation rate in cells treated with carbonyl cyanide-4-trifluoromethoxyphenylhydrazone (FCCP), a molecule that increases the permeability of the inner mitochondrial membrane to protons?
Part 1. The mitochondrial proton gradient would: A. Increase B. Decrease
Part 2. Mitochondrial respiration (mitochondrial oxygen consumption) would: A. Increase B. Decrease
Part 3. The NADH oxidation rate would:
A. Increase B. Decrease

Explanation / Answer

1. Decrease
FCCP treatment increases the permeability of the inner mitochondrial membrane for protons. This leads to the dissipation of the proton gradient.

2. Increase
As FCCP treatment increases the permeability of the inner mitochondrial membrane for protons, more oxygen is used to oxidize NADH to NAD+ to establish proton gradient for ATP synthesis.

3. Increase
As FCCP treatment increases the permeability of the inner mitochondrial membrane for protons, more oxygen is used to oxidize NADH to NAD+ to establish proton gradient for ATP synthesis.

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