Suppose a customer of a personalized genomics service has only protective allele

Question

Suppose a customer of a personalized genomics service has only protective alleles at all known QTLs for a trait with very low heritability in the population. Suppose another customer has only protective alleles at all known QTLs for a trait with very high heritability in the population.
Assume the heritability is the only factor that differs between the two scenarios.

a) If a customer engages in activities that increase disease risk, in which case will it have a bigger impact on the customer's disease susceptibility?

b)Why?

Explanation / Answer

Ans (a) :- Risk perceptions – or an individual’s perceived susceptibility to a threat – are a key component of many health behavior change theories. Risk perceptions are often targeted in health behavior change interventions, and recent meta-analytic evidence suggests that interventions that successfully engage and change risk perceptions produce subsequent increases in health behaviors. Here, we review recent literature on risk perceptions and health behavior, including research on the formation of risk perceptions, types of risk perceptions (including deliberative, affective, and experiential), accuracy of risk perceptions, and associations and interactions among types of risk perceptions. Taken together, existing research suggests that disease risk perceptions are a critical determinant of health behavior, although the nature of the association among risk perceptions and health behavior may depend on the profile of different types of risk perceptions and the accuracy of such perceptions.

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