14. DNP (2,4-dinitrophenol) is a weight-loss agent used in the 1930s. It has sin

Question

14. DNP (2,4-dinitrophenol) is a weight-loss agent used in the 1930s. It has since been removed from the market (though it is available online) because of serious side effects that include death. DNP inserts into the inner mitochondrial membrane and allows protons to flow between the intermembrane space and the matrix. Based on this information, which of the following might you predict result from DNP use? (Select all that apply.) - reduction of the proton gradient across the inner mitochondrial membrane reduced ATP production increased ATP production enhanced proton gradient across the inner mitochondria membrane

Explanation / Answer

reduction of the proton gradient across the inner mitochondrial membrane. Proton gradient is due to transport of proton from matrix to intermembrane space. DNP will result in diffusion of protons from intermembrane space to matrix resulting in loss of the proton gradient.

reduced ATP production. Since proton motive force is used by ATP synthase to produce ATP from ADP and Pi, reduction in proton gradient will result in loss of proton motive force and hence ATP production will reduce.

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