Sex linked The X and Y chromosomes segregate into gametes much as a pair of alle

Question

Sex linked The X and Y chromosomes segregate into gametes much as a pair of alleles would. Half of the sperm will receive a Y chromosome and half will receive an X. All the eggs receive an X. If the female is heterozygous at an X linked locus, half of her eggs will contain an X with one of the alleles on it and half will contain an X with the other allele on it. 10. Ron has mild hemophilia that the can control by taking a clotting factor. He married Lydia, whom he met at the hospital where he and Lydia

Explanation / Answer

Because Marvin is affected by hemophilia, it means his parents must either be carriers or express the disease. However the question states that their parents don't have the disorder. Their father cannot be a carrier because hemophilia A is a recessive X linked disorder, meaning if their father has a diseased X chromosome, he would express it. This leads to their mother being a heterozygote carrier for hemophilia. Since Lydia receives an X chromosome from each parent she is also a heterozygote carrier for hemophilia. If Reginald and Lydia conceive a child that is female (receiving an X from mom and dad) she would have a 50% chance of having the disorder depending if her mother gives the affected X chromosome. This is also true if the baby is male. There is a 50% chance that the male child will be express the disorder depending on whether or not he gets the affected X chromosome from his mother.

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