Using the structure, convince yourself that the helix has H-bonds between the nt
ID: 275995 • Letter: U
Question
Using the structure, convince yourself that the helix has H-bonds between the nth and (n+4)th amino acid residues in the helix. Does this number of atoms correlate with the 3.6 residues per turn value given in the text?
Using the structure of the side chains, determine the sequence of the peptide shown here. Remember to record your answer from N-terminus to C-terminus using the one-letter amino acid code.
Looking at the structure, do you think a D-amino acid could be incorporated into the ?-helix? Which direction would the side chain point?
Explanation / Answer
alpha-helix is a structure often found in many proteins. The H bonds are formed between N-H and C=O group of amino acid residues that is 4 residues earlier.This corresponds to 3.6 residues per turn.
The structure of the helix, assuming Reds as carboxyl oxygen,NH groups as Blue, greys as side chains;
N terminal (bottom) ...LY......M..C (terminal)
Alpha helix is a right handed structure, with L-amino acids incorporated. Only D-amino acids in the helix would change the helix to left handed structure.
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