8. The figure below illustrates a signal transduction pathway involving a G prot

Question

8. The figure below illustrates a signal transduction pathway involving a G protein-coupled recepton and the two second messengers IP3 and DAG. Lithium inhibits this pathway in two places. As a result, calcium ion levels within the cytoplasm stay low and there are lower levels of active phospholipase C. Based on this information and the figure shown, what are the two most likely places that lithium will block the pathway? Outside of cell Hormone Phospholipase C Receptor DAG Cellular IP3 Lumen of smooth endoplasmic reticulum o Ca2+ Inside of cell High Ca2+ Hormone binding and PIP2 hydrolysis G protein activation and IP3 formation Phospholipase C activation and protein kinase C activation G protein activation and protein kinase C activation. Receptor activation and protein kinase C activation.

Explanation / Answer

The answer is B

G-protein activation and IP3 formation.

Lithium inhibits G-protein activity so there are low levels of PLC thus inhibits the hydrolysis of PIP2 and IP3 formation leading to low level of Calcium.

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