QUESTION 7 A researcher is testing a chemical inhibitor of NF-kB. It is found to

Question

QUESTION 7

A researcher is testing a chemical inhibitor of NF-kB. It is found to be non-toxic and she receives approval to perform animal studies. She gives the inhibitor to rabbits and performs various tests. What is she MOST likely to observe in these rabbits?

A hyperactive immune response skewed towards production of TNF? and IL-1.

A hyperactive immune response skewed towards production of type I IFNs.

Immunodeficiency with a susceptibility to bacterial infections.

Immunodeficiency with a susceptibility to viral infections.

QUESTION 8

1 point possible (graded)

An antibody is being studied that is specific for a toxin secreted by a bacterial species. The toxin causes gastrointestinal symptoms. When rabbits are injected with the antibody, they are protected from the effects of the injected toxin. How do these antibodies work?

antibody-dependent cellular cytotoxicity

complement fixation

neutralization

opsonization

Explanation / Answer

Q7

NF-?B (nuclear factor kappa light chain enhancer of activated B cells) is a family of highly conserved transcription factors that play a role in the regulation of inflammatory responses, cellular growth, adaptive immunity, B-cell development, and apoptosis So, the inhibitor of the NF-?B will cause Immunodeficiency in the organism, which is susceptible to bacterial infections.

Hence, the correct option is Immunodeficiency with a susceptibility to bacterial infections.

Q8.

These antibodies work by neutralizing the toxin.

Hence, the correct option is neutralization.

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