10 Which of the following statements about growth hormone (GH) actions in the bo

Question

10 Which of the following statements about growth hormone (GH) actions in the body is INCORRECT?

A GH stimulates local synthesis of insulin-like growth factor (IGF-1) in most target tissues

B GH stimulation of growth in children is dependent upon insulin-like growth factor (IGF-1)

C GH stimulates insulin-like growth factor (IGF-1) synthesis and secretion from the liver

D Binding of GH to its receptor activates the JAK2/STAT5 signalling pathway in many target cells

E GH has few direct effects of its own and largely depends on insulin-like growth factor (IGF-1) as a mediator

Explanation / Answer

E GH has few direct effects of its own and largely depends on insulin-like growth factor (IGF-1) as a mediator

is incorrect.

GH has direct effects on most tissues, including skeletal muscle. GH binding results in dimerization of two GH receptors and intracellular signalling involves the Janus kinase and the signal transducers and activators of transcription (Stat) pathway. However, GH stimulates the synthesis of IGF-I in some tissues as a mediator.

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