Kuru is an incurable degenerative neurological disorder endemic to tribal region

Question

Kuru is an incurable degenerative neurological disorder endemic to tribal regions of Papua New Guinea. It is a type of missible spongiform encephalopathy, caused by a prion. Prions are misfolded protein molecules, which propagate by transmitting a misfolded protein state. If a prion enters a healthy organism, it induces xisting, properly folded pro convert into the disease-associated, misfolded prion form; the prion acts as a template to proteins into prion form. These newly formed prions can then go on to convert more proteins themselves. Which of the following is true about individuals suffering from a prion disease? trans . They have a mutation in the prion protein Their DNA has the incorrect sequence Atleast onc of the amino acids in the protein has been changed The protein lost its tridimensional structure They have a mutation in the chaperone protein that initially folds the protein

Explanation / Answer

The correct answer is option E that is they have a mutation in the chaperone that initially folds the protein because chaperones are the proteins that help other proteins to fold properly. This means that when a person has prion disease, other misfolded protein cause mutation in chaperones and proteins are not able to fold properly.

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