Using the following initial genotypes, complete (as far as you can) the pedigree
ID: 279048 • Letter: U
Question
Using the following initial genotypes, complete (as far as you can) the pedigree below - You wll derive several genotypes. have to 1-1 150/130: 1-2 120/7: 1-3 120/130; 11-6 150/140; 1112 170/120; 111-5 130/130: 111-11 150/160 Disease phenotype is x-linked recessive Which of these is a possible genotype for lI-27 a) 140/120 b) 120 /120 c) 130/120 c) 130/120 b) 120/120c) 130/120 d) 160/120 d) 160120 d) 140/150 e) unable to determine Which of these is a possible genotype for l1-67 a)140/120 b) 1 20/120 e) unable to determine 21. Which of these is a possible genotype for 11-82 ., . . a) 140/120 e) unable to determine 22. Which of these is a possible genotype for 11-57 a) 140/120 b) 120/120 )130/120 d) 160/120 e) unable to determine 23. Which of these is a possible genotype for 111-7? a) 160/120 b) 130/150 c) 130/120 d) 150/120 e) All are possible 24. Which of these is a possible genotype for 11-7? a) 140/120 b) 130/150 130/140d) 140/140 e) None are possible Answer the following using the x-linked recessive Disease Phenotype (shaded individuals) data and the DISEASE genotypes that you can derive. 25. Which of the following must be a carrier? a) 11-2 26. Which of the following will not pass on the disease allele? a) All females not exhibitng the disease b) All progeny of males exhibiting the disease c) All progeny of females not exhibiting the disease d) All males not exhibiting the disease e) Unable to determine 27. Which of the following must pass on the disease allele to all of their progeny? a) 11-4 and 111-4 b) 1-2 and 11-8 c) 1-2 and III-5 d) -2 and 11-3 e) Unable to determine 28. Assuming II-1 is not a carrier, what percent of the progeny from 11-1 and 11-2 will be carriers? a) 0% 29. Using the provided and derived genotypes, what percent of the progeny from Il-3 and Il-4 will be carriers? b) I1I-8 c) 11-9 d) I11-3 e) Unable to determine b) 25% c) 50% d) 75% e) 100% b) 25% c) 50% d) 75% e) 100% a) 096 30. Using the provided and derived genotypes, what percent of the progeny from II-8 and I1-9 will be carriers? b) 25% c) 50% d) 75% e) 10096
Explanation / Answer
The genotype of I-1 is 150/130.
The genotype of II – 3 is 120/130.
The genotype of II – 6 is 150/140.
It is given that the genotype of I-2 is 120/?
From the genotypes of II-3 and II-6, it can be deduced that the genotype of I-2 is 120/140.
Logic: Individual II-6 inherited allele 150 from II-1. Therefore, the allele 140 must be from parent I-2.
Therefore, the genotype of parent I-2 is 120/140.
Reason: The possible combinations that II-2 can inherit is (150/120), (130/120), (150/140), and (130/140). The only correctoption given in the answer choices is 130/120.
Reason: The parents of III-6 are not known. Hence, the genotype cannot be determined without any information
21. The possible genotype for II-8 is (e) unable to determine
Reason: The possible genotypes of II-8 are (150/120), (130/120), (150/140), and (130/140). However, in the answer choices, both the genotypes (130/120), and (140/150) are present.
22. The possible genotype for II-5 is (c) 130/120.
23. Answer is (e) all are possible. The genotype of the individual II-4 is not known. Hence, any of the given genotypes is possible.
24. The possible genotype for II-7 is (c) 130/140.
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