28. The conformation of hemoglobin undergoes global changes with the binding and

Question

28. The conformation of hemoglobin undergoes global changes with the binding and release of 02 including an increase in the pKR of histidine HC3 when hemoglobin is in the deoxy (T) form because of a change in its microenvironment. Predict the effect of each of the following environmental changes of the pk (increase or decrease) of a glutamic acid R group under the following conditions. a. A lysine R group is brought into proximity. b. The terminal carboxyl group of the protein is brought into close proximity

Explanation / Answer

Pka is the side chain of the amino acid.this can interact with the other residues of the enzymes and this greatly effect the pka value.pka consists of both carboxylic group ad amino group.the binding site in the receptor is much favoured than the plasma or the cellular proteins because of the presence of suitable functional group that strongly interact with the drug molecule.

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