THINKING LAB Identifying Mutations and Predicting Their Consequences Background
ID: 279499 • Letter: T
Question
THINKING LAB Identifying Mutations and Predicting Their Consequences Background As you have seen, a change in a single nucleotide makes the difference between a normal hemoglobin protein and the altered protein associated with sickle cell disease. This table shows nucleotide sequences from different forms of an imaginary gene. In this lab, you will examine these sequences to identify different types of mutations and predict their consequences. Gene type Nucleotide sequence (from template DNA strand) wild (normal) Mutant 1 Mutant 2 Mutant 3 TACCTCTTTCGGGTAACAATAACT TACCTCTTTCGGGTAACTAATAACT TACCTCTTTCGGGTGACAATAACT TACCTCTTTCGGGTAAAAATAACTExplanation / Answer
Answer=
1]
wild type (normal) = DNA STRAND =
TAC CTC TTT CGG GTAACAATAACT- DNA strand
AUG GAG UUU GCC CAU UGU UAU UGA - mRNA strand
met- Glu - phe - Ala - His -Cys - Tyr - polypeptide
----------------------------------------------------------------------------------------------------------------------
Mutant 1
DNA template - TACCTCTTTCGGGTAACTAATAACT
mRNA STRAND - AUG GAG AAA GCC CAU UGA UUA UUG A
polypeptide - met - Glu - Lys -- Ala- His
-----------------------------------------------------------------------------------------------------------------------------------
Mutant 2 ]
DNA strand -TACCTCTTTCGGGTGACAATAACT
mRNA - AUG GAG AAA GCC CAC UGU UAU UGA
Polypeptide - met - Glu - Lys - Ala -His -Cys - Tyr
----------------------------------------------------------------------------------------------------------------------------
Mutant 3]
DNA strand - TACCTCTTTCGGGTAAAAATAACT
mRNA strand - AUG GAG AAA GCC CAU UUU UAU UGA
Polypetide - met -Glu - Lys - Ala - His - Phe - Tyr
=======================================================================================
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.