REFERENCES 339 Question 10-4: A company has developed an improved sequencing met

Question

REFERENCES 339 Question 10-4: A company has developed an improved sequencing methodology and has offered to generate near- perfect sequences of 100,000 people. Who should be sequenced, why, with what accompanying details, and with what safeguards on the information? Question 10-5: The geographical ancestry of a DNA sample can readily be deduced from its sequence. Does this prove that human races exist? Question 10-6: What evidence suggests that the EDAR gene has experienced positive selection in humans? What additional analysis or experiment would you perform to identify the target(s) of selection and the selective force?

Explanation / Answer

10-4) A company has developed an improved sequencing methodology and offered to generate near perfect sequences if 100000 people. The people who should be included in this project should be a sample representing the entire human population. So, samples should be collected from persons living in all the parts if the world belonging to different races, countries, languages and continents. There should be an equal representation of men and women. Petsons suffering from few common genetic disorders should also be included.

10-5) The geographical ancestry of DNA sample can be deduced from its sequence. This doesn't prove that human race exist because human DNA is ninety percent similar to the DNA of lower organisms like fruit fly (drosophila).

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