Considering DNA replication Select the correct statements Select one or more: a.

Question

Considering DNA replication Select the correct statements Select one or more: a. The lagging strand is the DNA template on which Okazaki Fragments are synthesized. b. Lipids and carbohydrates are the two categories of macromolecules not involved in DNA replication (enzymes, templates, monomers, macromolecules). O c. Replication occurs by a conservative mechanism where two parent strands serve as a template for the synthesis of two nascent strands. d. Commences at promoter regions where the replication machinery, including DNA polymerase, assembles after RNA polymerase synthesizes a short, complementary RNA "primer." e. Errors in nucleotide incorporation are the most likely source of heritable, permanent mutations. However, replication can use various DNA polymerases to proof-read and correct 'incorrect' nucleotides. O f. All of the above are false. Which features are common between Mismatch repair and excision repair? Select all that apply Select one or more: O a. They both require DNA polymerase I O b. They both can repair mistakes made during DNA replication c. They both require the breakage of phosphodiester bonds d. Both are mechanisms to repair damage caused by exogenous agents like UV e. None of the listed features are shared between the two mechanisms

Explanation / Answer

Considering DNA replication, correct statements are:

a. The lagging strand is a DNA template on which Okazaki fragments are synthesized.

b. Lipids and carbohydrates are the two categories of macromolecules not involved in DNA replication. DNA replication requires enzymes(proteins), DNA template and primers.

e. Errors in nucleotide incorporation are the most likely source of heritable, permanent mutaions, However, replication can use various polymerases to proof-read and correct 'incorrect' nucleotides.

During replication, DNA polymerase sometimes incorporates wrong nucleotide, DNA polymerases are complex enzymes that not only synthesize DNA, but also check the accuracy of their actions, they are involved in a process called proofreading in which they can back up and excise remove incorrect nucleotide and incorporate correct nucleotide.

Common features between Mismatch repair and excision repair:

e. none of the listed features are shared between the two mechanisms

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