The pedigree bellow represents the inheritance of color blindness through three

Question

The pedigree bellow represents the inheritance of color blindness through three generations Which is statement about the genotype of Alissa and Haley regarding color blindness? a. Alissa is homozygous dominant, and Haley is a carries. b. Alissa is a carrier, and Haley is homozygous dominant. c. Both carry one recessive allele. e. Their genotype cannot be determined. For application in gene therapy, what is the most favorable characteristic of retroviruses? a. Retroviruses have an RNA genome. b. Retroviruses possess reverse transcriptase. c. DNA copies of retroviral genomes become integrated into the genome of the infected cell. d. Retroviruses mutate often. e. Retroviruses are wide spread and the human cells already have been exposed to them. An original section of DNA has the base sequence AGCGTTACCGT. A mutation in this DNA strand results in the base sequence AGGCGTTACCGT. This change represents. A) missense mutation B) a point mutation C) a silent mutation D) frame shift mutation E) a nonsense mutation Match the RNAs below with their function. Use each answer only once. a. Facilitates attachment of amino acids by ribosomes. b. Structural component of ribosomes. c. Transcripts of protein coding genes. d. Maturation of transcripts A) mRNA (c); tRNA (b); rRNA (d); snRNA (a) B) mRNA (d); tRNA (b); rRNA (c); snRNA(a) C) mRNA (a); tRNA(b); rRNA (c); snRNA (d) D) mRNA (c); tRNA (a); rRNA (b); snRNA (d) E) mRNA (b); tRNA (a); rRNA (d); snRNA (c)

Explanation / Answer

Answers:

(52) c

Colour blindness is a sex linked inheritance. For a woman to be colourblind, she should be homozygous recessive, that is both her X-chromosomes should carry the allele for colour blindness. Both Alissa and Haley are heterozygous and receives the colourblind allele in the X-chromosome from Barbara (Mother who is colourblind and homozygous) and normal X chromosome from Art (Father).

(53) c

Upon host cell infection, retroviruses can transform their single stranded RNA genome to double stranded DNA and integrates into the host genome. Thus, this property allows a permanent change in the host genome which is useful for gene therapy.

(54) D

Sequence: AGCGTTACCGT

Mutation: AGGCGTTACCGT

It is an insertion where G is inserted between G and C (shown in the diagram). It leads to a change in reading frame, that is frame shift mutation.

(55) D

mRNA- contains sequence which encodes for proteins

tRNA- carries the corresponding amino acids for translation in the ribosome

rRNA - About 60% of the ribosome is composed of rRNA

snRNA- small nuclear RNAs are small RNA species involved in splicing and RNA processing

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