3) (10 pts.) You are working in a lab with a mouse that can walk normally but is

Question

3) (10 pts.) You are working in a lab with a mouse that can walk normally but is unable to run. Your lab speculates that it has something to do with the muscle physiology itself as the neuronal structure is all normal. You are also able to confirm that muscle cell membranes carry action potentials, and that the DHPR-RyR protein complex functions normally. Given that these parts of the system are working normally, describe what else might be the cause of reduced ability to repeatedly contract muscle in these mice. Explain your reasoning

Explanation / Answer

1. Ryr or Ryanodine receptor- part of calcium channel

2. DHPR or Dihydropyridine receptor - part of calcium channel

3. Csq or Calsequestrin- traps calcium ion inside sarcoplasmic reticulum

4. Triadin- integral membrane protein of sarcoplasmic reticulum.

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