The cutaneous immune system: a. Comprises a large surface area b. Contains kerat

Question

The cutaneous immune system: a. Comprises a large surface area b. Contains keratinizing stratified squamous c. d. Contains Langerhan's cells for epidermal sampling All of the above Intestinal macrophages have a unique phenotype that enables them to: a. Phagocytose and kill microbes but at the same time to secrete anti-inflammatory cytokines, such as I-10 b. Produce overwhelming amounts of inflammatory cytokines in response to bacterial antigens c. Enhanced PAMPs recognition by PRRs d. Prime naive alpha/beta T cells 49. so. The major form of adaptive immunity in the gut consists of Humoral immunity directed at microbes in the lumen Intestinal macrophages that phagocytose and kill microbes but remain "unstimulated a. c. Direct response by TLRs and NLRs d. None of the above b. S1. A common feature of DCs and epithelial cells in the gut is the compartmentalization and low expression levels of which minimizes inflammatory responses to commensal bacteria in the lumen but promotes responses against microbes that penetrate the lamina propria. a. Transcription factors b. Pattern recognition receptors (i.e. TLRs and NLRs) d. Calcium channels Inflammatory cytokines Which of the following antibody isotypes dominates humoral immunity in the gut? a. IgG 52. c. Dimeric lgA d. IgE S3. The dominant protective cell-mediated immune response in the gut consists of c Ta memory cells d. Te effector cells a. T, effector cells b. Tr memory cells 54. The adaptive immune system in the gut must continuously suppress potential immune responses to food antigens and commensal microbial antigens to prevent inflammatory reactions that would compromise the mucosal barrier. What other regional systems exhibit the same or a higher degree of "commitment" to maintain tolerance? a. The respiratory system b. The genitourinary tract c The brain and testes Nowhere else in the body is there such an extensive commitment of the immune system to maintaining tolerance to foreign antigens d. 55. Which of the following is true about microbial antigen sampling by DCs residing in the lamina propria of the gut? Lamina propria DCs can only sample antigens via M cells Lamina propria DCs can extend cytoplasmic processes between intestinal epithelial cells and reach into the intestinal lumen to sample microbial antigens Lamina propria DCs can only receive antigens that have been previously opsonized by antibodies and subsequently bound by Fe receptors No DC in GALT is capable of antigen sampling or processing a. b. c. d. Which of the following cytokines is/are known to down-regulate inflammation and promote tolerance in the gut? a. b. 56. IFN-? and TNF-? TGF-B1 and IL-9 C. TGF-B1 and IL-10 d. TGF-B1 and IL-6

Explanation / Answer

Answer -

Question 48. The option (c) is correct .contain Langerhans cells for epidermal sampling.

Explanation - skin have huge glands which secrete chemical which provides innate immunity also a physiological barrier. In skin Langerhans cells present which interact with pathogen and kills them.

Question 49. The option (a ) is correct. Phagocytes and kill microbes but at the same time secrete anti inflammatory factor.

Explanation - Macrophages are phagocytic in nature. They interact and phagocyte the pathogen. At that time intestinal mucosa secrete anti inflammatory substance like IL-0.which prevent inflammatory and anti bacterial property.

Question 50. The option (a) is correct. Humoral immunity directed at microbes in the lumen.

Explanation. In our gut system large number of cells present which are phagocytic in nature. They are secrete B - cells. Which interact with pathogen and kill them.

Question 51. The option (b) is correct. Pattern recognition factors.

Explanation - Because pattern recognition factors play important role in innate immunity. They recognise the pathogen and secrete chemical against it.

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.