You want to design a placebo-controlled study to evaluate calorie intake control

Question

You want to design a placebo-controlled study to evaluate calorie intake control of a new appetite suppressant. The primary outcome is the number of calories consumed per day,a continuous variable, which will be measured after 1 week of beginning the trial. You expect to lose 10% of the participants over the course of follow-up. The mean calorie intake rate in adults is 2,400 calories per day with a standard deviation of 450. How many subjects should be enrolled to ensure 80% power to detect a difference of 200 calories per day with a two sided test and an alpha 0.05? 5.

Explanation / Answer

standard deviation                  =   = 450 for 0.05 level and two tailed test critival value Z/2 ± 1.9600 for 0.2 level of type II error critival value Z = 0.8416 required sample size             =n =(Z/2+Z)22/(o-a)2 = 40.00

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