Question 10 0.5 pts In a cohort study that investigated the association between

Question

Question 10 0.5 pts In a cohort study that investigated the association between eating daily intake of cruciferous vegetables and cancer, the following was observed 50 ate cruciferous vegetables daily and was diagnosed with cancer at the end of follow-up -100 did not eat cruciferous vegetables and was diagnosed with cancer at the end of follow-up 50 ate cruciferous vegetables daily and was not diagnosed with cancer at the end of follow-up 50 did not eat cruciferous vegetables and was not diagnosed with cancer at the end of follow-up. When comparing the RR and OR of the relationship between daily consumption of cruciferous vegetables and cancer, which statement best explains your observation OR is not an appropriate approximation of RR because the exposure of interest is not rar O Cannot really compare because we need to repeat the study using the case-control study design O OR is an appropriate approximation of RR because they are measuring associations the same way O OR is not an appropriate approximation of RR because the outcome is not rare.

Explanation / Answer

Risk Ratio= Risk of Event in treatment group/ Risk of Event in control group

Risk of Event in treatment group=50/(50+50)=0.5

Risk of Event in control group=100/(100+50)=0.66

Risk Ratio=0.76

Odds Ratio= Odds of event in treatment Group/ Odds of event in Control group

Odds of event in treatment Group=50/50=1

Odds of event in control group=100/50=2

Odds ratio=1/2=0.5

Relative risk can be directly determined in a cohort study by calculating a risk ratio. An OR can overestimate and magnify risk, especially when the disease is more common. iI the prevalance of disease is less than 10%, relative risk and odds ratio would be approximately same

OR is not an appropriate approximation of RR because the outcome is not rare

Option (d)

Cancer No-cancer Eat Cruciferous Vegetable 50 50 Did not Eat Cruciferous Vegetable 100 50

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