In 1998 one thousand men aged 65-80 years were examined for the presence of pros

Question

In 1998 one thousand men aged 65-80 years were examined for the presence of prostate cancer, of those 1,000 men, 197 had detectable prostate cancer in 1998. Of those free from prostate cancer in 1998 all were followed from Jan 1st 1999 through December 31, 2004. One hundred men were lost to follow-up and 388 died of other causes (assume they were lost or died midway through the follow-up period). Assume the lost-to-follow up subjects and the deaths occurred in the middle of the study period. During the 6-year follow-up 98 men developed prostate cancer. One hundred percent of the men who developed prostate cancer during the study period were still alive and included by the end of the study period. None of them were cured. What is the cumulative incidence (CI) for prostate cancer for the period between Jan 1, 1999 and Dec 31, 2004? a. 98/803=0.122 or 122 per 1000 persons b. 100/388=0.257 or 257 per 1000 persons c. 388/803=0.431 or 431 per 1000 persons d. 98/1000=0.098 or 98 per 1000 persons

Explanation / Answer

cumulative incidence =new cases of disease /population at risk except those who already have

=98/(1000-197)=98/803

option A is correct

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