In the following human pedigrees, the filled symbols represent the affected Indi

Question

In the following human pedigrees, the filled symbols represent the affected Individuals. You may assume that the disease allele is rare and therefore individuals marrying Into the family are unlikely to have defective allele. State the genotypes of individuals # 1-5 in the following table using the letter "A". Use the uppercase letter to represent the dominant allele and lowercase letter to represent the recessive allele. If individuals M 2 and 3 have another son what are the chances that this son will be affected? State the genotypes of individuals #6-8 in the following table using the letter "8" Use the uppercase letter to represent the dominant allele and lowercase letter to represent the recessive allele If Individuals #6 and #7 have another daughter who are the chance that she will be affected

Explanation / Answer

Question1

(a)

(i)Autosomal Dominant Inheritance

In autosomal dominant inheritance, only one copy of a disease allele is necessary for an individual to be susceptible to expressing the phenotype. With each pregnancy, there is a one in two (50%) chance the offspring will inherit the disease allele.

(ii)

Individual

Genotype

1

aa

3

aa

4

Aa

5

aa

Individual

Genotype

1

aa

3

aa

4

Aa

5

aa

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