The drug reference manual states the following about the safe dose of midazolam

Question

The drug reference manual states the following about the safe dose of midazolam for a child older than 2 months who has status epilepticus: V (Children older than 2 months): 0.15 mg/kg load followed by a continual infusion of 1 mcg/kg min Titrate dose upward q 5 mm until seizure controlled, range: 1-18 mcg/kg/min. A child weighing 18 kg is brought into the ED with continuous seizure activity. The ED physician orders a loading dose of 2.5 mg IV midazolam followed by an IV infusion of midazolam. What is the maximum loading dose for this child? Is the ordered loading dose safe?

Explanation / Answer

Maximum loading dose for the child= volume of drug per kg of patient x weight of the patient

= .15 mg/kg x 18

= 2.7 mg of midazolam.

Now here the ordered loading dose of 2.5 mg is safe as it is less than the safe maximum loading (2.7 mg) for the child.

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