Hazard: The chemical is a neurotoxin. The major toxic effect is cell membrane di

Question

Hazard:
The chemical is a neurotoxin.
The major toxic effect is cell membrane disruption and acetylcholinesterase
inhibition.
Dose Response:
The acute lethal dose in humans = 5 mg/kg body weight (BW).
The minimal toxic effect = 1 mg/kg BW.
Exposure Assessment:
The residue of the chemical in potato tubers averages 100 mg/kg fresh weight.
The daily average potato consumption per person in the US is 0.167 kg fresh
weight.
Questions to Answer (2 points each) (Show Your Work):
a. What is the ingested dose of the chemical residue per day per person?
b. What is the ingested dose of the chemical per kg BW for adults (assume 70
kg/adult)?
c. Express the risk in terms of percentage of the minimal toxic effect.
d. Express the risk in terms of percentage of the acute lethal dose.
e. Express the risk in terms of percentage if the EPA's acceptable daily intake is
0.005 mg/kg BW. This regulatory endpoint assumes that the no-observed-effectlevel
(NOEL) = 0.5 mg/kg BW and there is a 100-fold safety factor built in.

Explanation / Answer

Please find the answers below:

a.What is the ingested dose of the chemical residue per day per person?

Ans: = daily average potato consumption per person in the US is 0.167 kg fresh weight *  chemical in potato tubers averages 100 mg/kg fresh weight

= 0.167*100 = 16.7mg

b.What is the ingested dose of the chemical per kg BW for adults (assume 70
kg/adult)?

Ans: 16.7mg per day per adult

c: Express the risk in terms of percentage of the minimal toxic effect.

Ans: (1/5) * 100 = 20%

d.  Express the risk in terms of percentage of the acute lethal dose.

Ans: (16.7/5) *100 = 330%

e.Express the risk in terms of percentage if the EPA's acceptable daily intake is
0.005 mg/kg BW. This regulatory endpoint assumes that the no-observed-effectlevel
(NOEL) = 0.5 mg/kg BW and there is a 100-fold safety factor built in.

Ans: (0.005/ 5) *100 = ,1%

Related Questions

Navigate

• Browse (All)
• Browse H
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.