The Physicians\' Health Study randomly assigned 22,071 healthy male physicians a

Question

The Physicians' Health Study randomly assigned 22,071 healthy male physicians at least 40 years old to take either an aspirin every other day or a placebo pill every other day. Of the 11897 physicians who took aspirin regularly for 5 years, 6 had a fatal heart attack and 122 had a nonfatal heart attack. Of the 10174 who took the placebo, 32 suffered a fatal heart attack and 234 had a nonfatal heart attack. Please use 4 decimal places to answer the questions below. What is the proportion of physicians who suffered a fatal heart attack in the: Calculate the relative risk of a fatal heart attack for physicians taking aspirin compared with those taking a placebo (do not use the rounded values from part (a) to do your calculations. Use the original proportions in your calculation. Remember, give your answer to 4 decimal places.). What is the proportion of physicians who suffered a nonfatal heart attack in the: Calculate the relative risk of a nonfatal heart attack, for physicians taking aspirin compared with those taking a placebo (do not use rounded values in your calculation and qive your answer to 4 decimal places).

Explanation / Answer

a) aspirin group: 6/11897=0.0005

placebo group: 32/10174=0.0031

b) Relative Risk=[6/(6+122)]/[32/(32+234)]=0.3896

c) aspirin group: 122/11897=0.010

placebo group: 234/10174=0.0230

d) RR=[122/(6+122)]/[234/(32+234)]=1.0835

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