What would happen if GTPase was substituted for GTP in G- Protein coupled recept

Question

What would happen if GTPase was substituted for GTP in G- Protein coupled receptor system which activates phospholipase C? Give examples What would happen if GTPase was substituted for GTP in enzyme linked receptor stsyem that activates Ras/MAP kinase and signals the cell to divide? Give examples What would happen if GTPase was substituted for GTP in G- Protein coupled receptor system which activates phospholipase C? Give examples What would happen if GTPase was substituted for GTP in enzyme linked receptor stsyem that activates Ras/MAP kinase and signals the cell to divide? Give examples What would happen if GTPase was substituted for GTP in enzyme linked receptor stsyem that activates Ras/MAP kinase and signals the cell to divide? Give examples

Explanation / Answer

A. If GTPase activity substituted for GTP , then GTP can not hydrolyse back to GDP and constitutively expressed so PLC always active . For example cholera toxin modify GPCR activity and leads to unregulated signaling.

B. In enzyme linked receptor if GTPase activity substituted then Ras remain always active leads to phosphorylation of other protein and unregulated growth occur. For example Cancer.

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