QUESTION 3 In the red blood cells (RBCs) from patients with sickle cell anemia (

Question

QUESTION 3 In the red blood cells (RBCs) from patients with sickle cell anemia (HbSS), hemoglobin gets denatured partially due to a loss in the proper distribution of celular membrane lipids. You are testing a drug for sickle cell anemia (HbSS). You measure the phospholipid content of RBCs following treatment in 12 patients. The following is the average lipid content(± the standard deviation) before and after treatment compared with 12 healthy control individuals who do not suffer from sickle cell anemia (HbAA) HbSS Untreated HbSS Treated HbAA (Healthy Control) 26.2+ 0.2 A. Phosphatidyl Choline B. Phosphatidyl Ethanolamine 9.8+0.1 C. Phosphatidyl Serine D. Sphingomyelin 24.6t 0.1 25.7 t 0.1 9.4 t0.4 9.7t0.4 15.3t 0.2 14.9 0.2 8.1t0.3 11.0+ 0.2 9.9t 0.3 15.3+ 0.3 The percentage of which lipid is changed the most in patients that suffer from HbSS (Sickle cell anemia)? a. PC O b. C. PS O d. SM

Explanation / Answer

Please find the answers below:

Answer 1: Choice a (the tabulated data clearly demonstrates a highly signifcant effect of drug treatment in the levels of PC)

Answer 2: Choice a (it can be seen clearly from the tabulated data that the concentration of PC is changed maximum by more than 2 units in the treated patients as compared to non-treated patients)

Answer 3: Choice b (the sickle-cell patients do not suffer from hematological disturbance related to blood-clotting, instead they suffer from disorder in which clumping of red blood cells takes place as these cells are deformed in shape. Since the drug is not capable of regulating the levels of PE in these cells which regulates the cellular membrane curvature, it is not considered as an effective drug)

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