You have three enzymes (E1, E2, and E3) that function in the same signaling path

Question

You have three enzymes (E1, E2, and E3) that function in the same signaling pathway, but you do not know the order in which they function. Mutation of any of the three enzymes results in a failure of the cell to respond to an extracellular signal. When cells have a permanently active version of any of the enzymes, they respond in the absence of ligand. You also have the following pieces of data. What is the order in which these enzymes function? When E1 is permanently active, and E2 and E3 are permanenty inactive, the cells do not respond in the absence of ligand. When E2 is permanently active, and E1 and E3 are permanently inactive, the cell responds in the absence of signal. When E3 is permanently active, E1 is permanently inactive, and E2 is unchanged the cell esponds in the absence of ligand. When E1 is permanently active, E3 is permanently inactive, and E2 is unchanged, the cell does not respond in the absence of ligand.

Explanation / Answer

It is given that in presence of active E1, and E2, permanently inactive, the cells do not respond in the absence of ligand.

While, in case of activation of E2 and the E1 and E3 permanently inactive, cell respond in absence of signals.

When E3 is active, E1 is permanent inactive and E2 remains unchanged, the cell respond in absence of ligand.

When E1 is permanent active, E3 is permanently active, and E2 is unchanged the cell do not respond in absence of ligand.

As per the given data it can be said that, E2 alone can let the cell respond in the absence of ligand. on the other hand the active E1 without E3 can’t let the cell to respond in absence of ligand.

So, the presence of E2 is necessary for E1.

So the order will be

E2-------------E1-----------E3

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