A clinical trial is planned to compare an experimental medication designed to lo

Question

A clinical trial is planned to compare an experimental medication designed to lower blood pressure to a placebo. Before starting the trial, a pilot study is conducted involving seven participants. The objective of the study is to assess how systolic blood pressures change over time if left untreated. Systolic blood pressures are measured at baseline and again 4 weeks later. Is there a statistically significant difference in blood pressures over time? Run the test at a 5% level of significance.

Baseline: 120 145 130 160 152 143 126

4 Weeks: 122 142 135 158 155 140 130

Explanation / Answer

from above as p value is higher then 0.05, we can not conclude that there a statistically significant difference in blood pressures over time

before after difference(d) 120 122 2 145 142 -3 130 135 5 160 158 -2 152 155 3 143 140 -3 126 130 4 mean 0.500 std deviaition 4.9497 std error= std dev/(n)^(1/2) 3.5000 t stat= (d-0)/std error 0.1429 p value = 0.4497

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